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| N,N'-BIS(2-HYDROXYETHYL) PIPERAZINE | ||
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PRODUCT IDENTIFICATION |
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| CAS NO. | 122-96-3 |
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| EINECS NO. | 204-586-0 | |
| FORMULA | C8H18N2O2 | |
| MOL WT. | 174.24 | |
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H.S. CODE |
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TOXICITY |
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| SYNONYMS | 1,4-Piperazinediethanol; Di(hydroxyethyl)piperazine; | |
| N,N'-Bis(2-hydroxyethyl)piperazine; N,N'-Bis(beta-hydroxyethyl)piperazine; 1,4-Bis(2-hydroxyethyl)piperazine; | ||
| DERIVATION |
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CLASSIFICATION |
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PHYSICAL AND CHEMICAL PROPERTIES |
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| PHYSICAL STATE | white crystalline powder | |
| MELTING POINT | 133 - 136 C | |
| BOILING POINT |
215 - 220 at 50 mmHg | |
| SPECIFIC GRAVITY | ||
| SOLUBILITY IN WATER | Soluble | |
| pH | ||
| VAPOR DENSITY |
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REFRACTIVE INDEX |
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NFPA RATINGS |
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AUTOIGNITION |
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FLASH POINT |
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| STABILITY | Stable under normal conditions. | |
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GENERAL DESCRIPTION & APPLICATIONS |
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Piperazine is a heterocyclic compound containing four carbon atoms and two of
nitrogen at 1,4 position ( als called 1,4-hexahydropyrazine). It is a
deliquescent crystalline compound melting at 105 C; soluble in water, alcohol,
glycerol, and glycols. It is used as a main ingredient of anthelmintics used to
treat intestinal roundworms (ascariasis) infection in human and poultry and to
treat pinworms (enterobiasis; oxyuriasis) by altering cell membrane permeability
and causing hyperpolarization of the membrane. Piperazine is a moiety in
psychoactive drugs. Certain piperazine derivatives are suspected of ecstasy substitutes.
Benzylpiperazine is bannaed in many countries. Benzylpiperazine has been
used as a anthelmintic (antiparastic effect). Nitrogen in piperazine ring plays
an important role in biological research and drug manufacturing industry
including the preparation of anthelmintic, antiallergenic, antibacterial,
antihistamic, antiemetic and antimigraine agents. The piperazine ring and
piperazine derivatives are important cyclic components in industrial field as
raw
materials for hardener of epoxy resins, corrosion inhibitors, insecticides,
accelerators for rubber, urethane catalysts and antioxidants.
An example of 1-Amino-4-methylpiperazine application is to be used as an intermediate for pharmaceuticals ( Anti-tuberculostatic agent: Rifampicin). |
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| SALES SPECIFICATION | ||
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APPEARANCE |
white crystalline powder | |
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ASSAY |
99.0% min |
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MELTING POINT |
133 - 136 C | |
| TRANSPORTATION | ||
| PACKING | | |
| HAZARD CLASS | ||
| UN NO. | ||
| OTHER INFORMATION | ||
| Hazard Symbols: XI, Risk Phrases: 36/37/38, Safety Phrases: 26-37/39 | ||
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